Linkletter B A, Bruice T C
Department of Chemistry, University of California, Santa Barbara 93106, USA.
Bioorg Med Chem Lett. 1998 Jun 2;8(11):1285-90. doi: 10.1016/s0960-894x(98)00228-5.
DNG is a DNA analogue wherein the negatively charged phosphate backbone linkages have been replaced by achiral positively charged guanidinium linkages and has high affinity for complimentary DNA. The synthesis of these compounds in solution phase has been severely limited due to diminishing yields and solubility limitations. For the first time, an efficient solid-phase synthesis for oligomeric is reported.
二氮杂萘酮（DNG）是一种DNA类似物，其中带负电荷的磷酸主链连接已被非手性带正电荷的胍连接所取代，并且对互补DNA具有高亲和力。由于产率降低和溶解性限制，这些化合物在溶液相中的合成受到严重限制。首次报道了一种用于寡聚物的高效固相合成方法。
