脱氧核酸胍的设计与合成：一种DNA的聚阳离子类似物。
Design and synthesis of deoxynucleic guanidine: a polycation analogue of DNA.
作者信息
Dempcy R O, Almarsson O, Bruice T C
机构信息
Department of Chemistry, University of California, Santa Barbara 93106.
出版信息
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7864-8. doi: 10.1073/pnas.91.17.7864.
The basic strategy is described for the connection of nucleosides by guanidinium (g) linkers to provide the positively charged deoxynucleic guanidine putative antigene agents. The synthetic procedures are provided for d(gT)n. Molecular modeling of double-stranded [d(gT)10.d(Ap)10] and the triple-helical hybrids [d(Tp)10.d(Ap)10.d(gT)10] and [d(gT)10.d(Ap)10.d(gT)10] suggest modes of interaction and anticipated structural features.
描述了通过胍基（g）连接体连接核苷以提供带正电荷的脱氧核酸胍推定反基因剂的基本策略。提供了d（gT）n的合成程序。双链[d（gT）10.d（Ap）10]以及三螺旋杂种[d（Tp）10.d（Ap）10.d（gT）10]和[d（gT）10.d（Ap）10.d（gT）10]的分子建模表明了相互作用模式和预期的结构特征。
Zotero 插件