Cebrat Malgorzata, Strzadala Leon, Kisielow Pawel
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolf Weigl St. 12, 53-114 Wroclaw, Poland.
Cancer Lett. 2004 Mar 31;206(1):107-13. doi: 10.1016/j.canlet.2003.10.024.
Using cDNA-Representational Difference Analysis it was found that expression of Opg, Ctse, Krt2-4, Fut-2, 24p3 and Wif-1 genes was elevated in intestinal adenomas as compared to normal epithelial cells of Apc(Min/+) mutant mice. Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines. The possible role of Wif-1 over-expression in the etiology of colorectal cancer is discussed.
利用cDNA代表性差异分析发现，与Apc(Min/+)突变小鼠的正常上皮细胞相比，Opg、Ctse、Krt2-4、Fut-2、24p3和Wif-1基因在肠道腺瘤中的表达升高。在许多上皮细胞来源的肿瘤细胞系中也检测到了编码Wnt抑制因子-1的Wif-1的表达，包括两个人类结肠腺癌细胞系。本文讨论了Wif-1过表达在结直肠癌病因学中的可能作用。
