Carmichael A R, Bates T
The Princess Royal Hospital, Haywards Heath, Sussex, UK.
Breast. 2004 Apr;13(2):85-92. doi: 10.1016/j.breast.2003.03.001.
A woman's build, the risk of breast cancer and its subsequent prognosis seem to be related. In most but not all case-control and prospective cohort studies, an inverse relationship has been found between weight and breast cancer among premenopausal women. However, most large epidemiological studies have found that overweight or obese women are at increased risk of developing postmenopausal breast cancer. It is suggested that higher body mass index is associated with a more advanced stage of breast cancer at diagnosis in terms of tumour size but data on lymph node status is not so consistent. All treatment modalities for breast cancer such as surgery, radiotherapy, chemotherapy and hormonal treatment may be adversely affected by the presence of obesity. The overall and disease-free survival is worse in most but not all studies of prognosis of obese pre- and postmenopausal women with breast cancer.
女性的体型、患乳腺癌的风险及其后续预后似乎存在关联。在大多数（但并非所有）病例对照研究和前瞻性队列研究中，已发现绝经前女性的体重与乳腺癌之间存在负相关关系。然而，大多数大型流行病学研究发现，超重或肥胖女性患绝经后乳腺癌的风险增加。有人提出，较高的体重指数在肿瘤大小方面与乳腺癌诊断时更晚期的阶段相关，但关于淋巴结状态的数据并不那么一致。乳腺癌的所有治疗方式，如手术、放疗、化疗和激素治疗，都可能受到肥胖的不利影响。在大多数（但并非所有）关于肥胖绝经前和绝经后乳腺癌女性预后的研究中，总体生存率和无病生存率较差。
