Taddei Angela, Gasser Susan M
Department of Molecular Biology, University of Geneva, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland.
Biochim Biophys Acta. 2004 Mar 15;1677(1-3):120-8. doi: 10.1016/j.bbaexp.2003.11.014.
Technical advances in the imaging of GFP derivatives in living cells have improved our ability to determine the position and dynamics of specific chromatin loci. This approach, combined with genetics and functional assays, has shed new light on how nuclear compartments facilitate gene repression in yeast.
活细胞中绿色荧光蛋白(GFP)衍生物成像技术的进步提高了我们确定特定染色质位点位置和动态的能力。这种方法与遗传学和功能分析相结合,为核区室如何促进酵母中的基因抑制提供了新的线索。