Durrett Richard, Nielsen Rasmus, York Thomas L
Department of Mathematics, Cornell University, Ithaca, New York 14853, USA.
Genetics. 2004 Jan;166(1):621-9. doi: 10.1534/genetics.166.1.621.
We present a Bayesian approach to the problem of inferring the number of inversions and translocations separating two species. The main reason for developing this method is that it will allow us to test hypotheses about the underlying mechanisms, such as the distribution of inversion track lengths or rate constancy among lineages. Here, we apply these methods to comparative maps of eggplant and tomato, human and cat, and human and cattle with 170, 269, and 422 markers, respectively. In the first case the most likely number of events is larger than the parsimony value. In the last two cases the parsimony solutions have very small probability.
我们提出一种贝叶斯方法，用于推断分隔两个物种的倒位和易位的数量问题。开发此方法的主要原因是它将使我们能够检验关于潜在机制的假设，例如倒位轨迹长度的分布或谱系间的速率恒定性。在这里，我们将这些方法分别应用于茄子和番茄、人类和猫以及人类和牛的比较图谱，标记数量分别为170、269和422个。在第一种情况下，最可能的事件数量大于简约法得出的值。在后两种情况下，简约法的解决方案概率非常小。
