Chemikosova T S, Kamalova O A, Ibragimova Z N
Stomatologiia (Mosk). 2004;83(1):14-8.
Examinations of workers engaged in the production of chlorophenoxyherbicides showed high prevalence of diseases of the buccal and labial mucosa with a trend to development of hyperkeratosis (exfoliative cheilitis, hyperkeratosis of the tongue, lips, buccal mucosa (BM), flat form of the BM and red lip leukoplakia). Cytogenetic effects of toxins on BM result in an increase of keratinization level, higher incidence of nuclear abnormalities, and appearance of the micronuclei in BM epithelium. A direct relationship between the severity of these symptoms, duration of exposure, and intensity of workers' contact with chlorophenoxyherbicides was revealed. The complex of noninvasive and atraumatic methods used in our study helped evaluate the BM status and can be used not only for visual examination, but also for the diagnosis of transformation of the defense reaction of the epithelium into pathological process and for preclinical detection of precancer changes in BM.
对从事氯苯氧基除草剂生产的工人进行的检查显示，颊部和唇部黏膜疾病的患病率很高，并有发展为角化过度的趋势（剥脱性唇炎、舌、唇、颊黏膜角化过度、扁平型颊黏膜和红唇白斑）。毒素对颊黏膜的细胞遗传学影响导致角化水平升高、核异常发生率增加以及颊黏膜上皮中出现微核。研究发现这些症状的严重程度、接触时间和工人与氯苯氧基除草剂的接触强度之间存在直接关系。我们研究中使用的非侵入性和无创伤性方法组合有助于评估颊黏膜状态，不仅可用于目视检查，还可用于诊断上皮防御反应转变为病理过程以及颊黏膜癌前病变的临床前检测。
