Celik Ayla, Kanik Arzu
Department of Biology, Faculty of Science and Letters, Mersin University, Mersin, Turkey.
Environ Mol Mutagen. 2006 Dec;47(9):693-8. doi: 10.1002/em.20257.
Occupational exposure to wood dust is associated with the occurrence of nasal cancer. In this study, we investigated micronuclei and nuclear changes (NCs: binucleates, karyorrhexis, karyolysis, and the "broken egg" effect) in exfoliated buccal cells of 20 workers exposed to wood dust and 20 age- and sex-matched controls. Micronucleus frequency and the frequency of each of the NCs were significantly higher for wood workers than controls (P < 0.01). Cigarette smoking was associated with increased frequencies of micronuclei and NCs in the buccal mucosa epithelium cells of both the control and exposed groups. Our findings indicate that buccal cells of wood workers display increased levels of genotoxicity and toxicity, and that these biomarker responses may be related to the increased cancer risk among wood workers.
职业性接触木尘与鼻咽癌的发生有关。在本研究中，我们调查了20名接触木尘的工人以及20名年龄和性别匹配的对照者的脱落颊细胞中的微核和核变化（核变化：双核、核固缩、核溶解以及“破蛋”效应）。木工的微核频率和每种核变化的频率均显著高于对照组（P < 0.01）。吸烟与对照组和接触组颊黏膜上皮细胞中的微核和核变化频率增加有关。我们的研究结果表明，木工的颊细胞显示出更高水平的遗传毒性和细胞毒性，并且这些生物标志物反应可能与木工患癌风险增加有关。
