Müller Stefan, Ledl Andreas, Schmidt Darja
Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
Oncogene. 2004 Mar 15;23(11):1998-2008. doi: 10.1038/sj.onc.1207415.
Post-translational modification with the ubiquitin-like SUMO protein is involved in the regulation of many cellular key processes. The SUMO system modulates signal transduction pathways, including cytokine, Wnt, growth factor and steroid hormone signalling. SUMO frequently restrains the activity of downstream transcription factors in these pathways presumably by facilitating the recruitment of corepressors or mediating the assembly of repressor complexes. Additionally, evidence is accumulating that SUMO controls pathways important for the surveillance of genome integrity. SUMO regulates the PML/p53 tumour suppressor network, a key determinant in the cellular response to DNA damage. Moreover, proteins that maintain genomic stability by functioning at the interface between DNA replication, recombination and repair processes undergo SUMOylation. We will discuss some key findings that exemplify the role of SUMO in transcriptional regulation and genome surveillance.
类泛素小泛素样修饰蛋白（SUMO）的翻译后修饰参与了许多细胞关键过程的调控。SUMO系统调节信号转导通路，包括细胞因子、Wnt、生长因子和类固醇激素信号传导。SUMO通常通过促进共抑制因子的募集或介导阻遏复合物的组装来抑制这些通路中下游转录因子的活性。此外，越来越多的证据表明，SUMO控制着对基因组完整性监测至关重要的通路。SUMO调节PML/p53肿瘤抑制网络，这是细胞对DNA损伤反应的关键决定因素。此外，在DNA复制、重组和修复过程之间的界面发挥作用以维持基因组稳定性的蛋白质会发生SUMO化。我们将讨论一些关键发现，这些发现例证了SUMO在转录调控和基因组监测中的作用。
