小泛素样修饰蛋白（SUMO）修饰对转录因子活性的调控

Regulation of transcription factor activity by SUMO modification.

作者信息

Ouyang Jian, Valin Alvaro, Gill Grace

机构信息

Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA.

出版信息

Methods Mol Biol. 2009;497:141-52. doi: 10.1007/978-1-59745-566-4_9.

DOI:10.1007/978-1-59745-566-4_9

PMID:19107415

Abstract

Post-translational modification by SUMO is an important mechanism to regulate transcription. Sumoyla-tion has diverse effects on substrate activity, but in most cases reported to date sumoylation of transcription factors correlated with transcriptional repression. Here we describe general strategies to address how post-translational modification by SUMO regulates the activity of a DNA-binding transcription factor.

摘要

由小泛素样修饰蛋白（SUMO）介导的翻译后修饰是调节转录的重要机制。SUMO化对底物活性具有多种影响，但迄今为止报道的大多数情况下，转录因子的SUMO化与转录抑制相关。在此，我们描述了一些通用策略，以探讨SUMO介导的翻译后修饰如何调节DNA结合转录因子的活性。