Ehninger A, Mziaut H, Solimena M
Experimental Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany.
Horm Metab Res. 2007 Sep;39(9):658-64. doi: 10.1055/s-2007-985372.
Post-translational attachment of small ubiquitin-like modifier (SUMO), defined as SUMOylation, can affect the localization, interactions, stability and/or activity of substrate proteins, and thus can participate in a large variety of cellular processes. Most SUMO substrates are involved in transcriptional regulation. Hence, SUMOylation can either activate or, more commonly, repress gene transcription. The modulation of gene expression by SUMO through diverse mechanisms and specifically the recent findings concerning SUMOylation in pancreatic beta-cells are reviewed.
小泛素样修饰物（SUMO）的翻译后附着，即SUMO化，可影响底物蛋白的定位、相互作用、稳定性和/或活性，进而参与多种细胞过程。大多数SUMO底物都参与转录调控。因此，SUMO化既可以激活基因转录，也更常见地是抑制基因转录。本文综述了SUMO通过多种机制对基因表达的调节作用，特别是胰腺β细胞中SUMO化的最新研究发现。
