Ljungvall Karl, Tienpont Bart, David Frank, Magnusson Ulf, Törneke Karolina
Department of Obstetrics and Gynaecology, Swedish University of Agricultural Sciences, Centre for Reproductive Biology in Uppsala, Box 7039, 750 07.
Arch Toxicol. 2004 Jul;78(7):384-9. doi: 10.1007/s00204-004-0558-z. Epub 2004 Mar 12.
Di(2-ethylhexyl) phthalate (DEHP) is used as a plastic softener in the polymer industry and is widespread in medical devices. DEHP has been incriminated as an endocrine-disrupting chemical, and the effects of DEHP in various species have included disturbances in the reproductive system. The effects of the chemical have varied, depending upon exposure routes and species. This study was performed in order to characterise the kinetics of DEHP and its metabolite mono(2-ethylhexyl) phthalate (MEHP) in the young male pig, an omnivore model-species for research in reproductive toxicology. Eight pigs were given 1000 mg DEHP/kg bodyweight by oral gavage. The concentrations of DEHP and MEHP were then measured in the plasma and tissues of the pigs at different time points after administration. There was no consistent rise above contamination levels of concentrations of DEHP in the plasma of the pigs. However, the metabolite MEHP reached the systemic blood circulation. The half-life of MEHP in the systemic blood circulation was calculated to be 6.3 h. Absorption from the intestine was biphasic in six of the eight pigs and the mono-exponential elimination-phase started 16 h after the after the administration of DEHP. To conclude, MEHP consistently reaches the systemic circulation in the pig when DEHP is administered orally. The kinetic pattern of the parent substance on the other hand is more difficult to characterise.
邻苯二甲酸二（2-乙基己基）酯（DEHP）在聚合物工业中用作塑料软化剂，在医疗器械中广泛存在。DEHP被认为是一种内分泌干扰化学物质，它对各种物种的影响包括生殖系统紊乱。这种化学物质的影响因暴露途径和物种而异。本研究旨在表征DEHP及其代谢产物单（2-乙基己基）邻苯二甲酸酯（MEHP）在幼年雄性猪体内的动力学，幼年雄性猪是生殖毒理学研究中的杂食性模式物种。八头猪通过口服灌胃给予1000mg DEHP/kg体重。给药后在不同时间点测量猪血浆和组织中DEHP和MEHP的浓度。猪血浆中DEHP的浓度没有持续高于污染水平。然而，代谢产物MEHP进入了体循环。计算得出MEHP在体循环中的半衰期为6.3小时。八头猪中有六头从肠道的吸收是双相的，单指数消除期在给予DEHP后16小时开始。总之，口服DEHP时，MEHP在猪体内始终进入体循环。另一方面，母体物质的动力学模式更难表征。
