François Guido, Passreiter Claus M
Prince Leopold Institute of Tropical Medicine, Antwerpen, Belgium.
Phytother Res. 2004 Feb;18(2):184-6. doi: 10.1002/ptr.1376.
Four sesquiterpene lactones of the pseudo-guaianolide type (helenalin, dihydrohelenalin and their acetates), have shown activities against asexual blood forms of Plasmodium falciparum in vitro. Their IC(50) values were situated in the range of 0.23 to 7.41 micro M. The activity found for helenalin was high, even compared to the activity found for artemisinin.
四种伪愈创木烷型倍半萜内酯（海伦内酯、二氢海伦内酯及其乙酸酯）在体外已显示出对恶性疟原虫无性血液阶段的活性。它们的半数抑制浓度（IC50）值在0.23至7.41微摩尔范围内。发现海伦内酯的活性很高，甚至与青蒿素的活性相比也是如此。
