Guillot M, El Hachem C, Amiour M, Delaisi B, Reinert P
CRCM Lisieux, service de pédiatrie, CHG R. Bisson, 4, rue Aini, 14100 Lisieux, France.
Arch Pediatr. 2003 Dec;10 Suppl 5:588s-591s. doi: 10.1016/s0929-693x(03)90042-x.
Allergic bronchopulmonary aspergillosis (ABPA) should be suspected in any CF patient whose pulmonary disease deteriorates precipitously, suddenly or unexpectedly, and has to be correlated to fungal hypersensitivity biological tests. The standard therapeutic approach is based upon systemic corticosteroids. Invasive pulmonary aspergillosis (IPA) may occur mainly but not exclusively in immunosuppressed patients undergoing lung transplantation. New antifungal compounds (Triazoles, Itraconazole, Voriconazole), Echinochandins (Caspofungin) are effective, synergistic, well tolerated, should their contraindications and side effects be carefully respected and monitored.
