Lionet A, Barsumau J, Azar R
Service de néphrologie, Centre hospitalier de Dunkerque.
Nephrologie. 2004;25(1):29-32.
We report the case of a caucasian patient with a presentation of a periodic paralysis associated with hypokalaemia disclosing Graves' disease. Major pathophysiologics hypothesis are discused in order to explain relationships between hyperthyroidism and paralysis through a disturbance of the excitability of the muscle fibres. A genetic predisposition explain the high incidence of this affection in asiatic population while it is uncommon in caucasian race. Potassium supplementation is not needed in order to correct hypokalaemia except in case of cardiac disturbances. Treatment by beta-blockers is advisable with the specific treatment of hyperthyroidism.
我们报告了一例白种人患者，其表现为与低钾血症相关的周期性麻痹，最终诊断为格雷夫斯病。为了解释甲状腺功能亢进与麻痹之间通过肌纤维兴奋性紊乱的关系，我们讨论了主要的病理生理假说。遗传易感性解释了这种疾病在亚洲人群中的高发病率，而在白种人中并不常见。除了心脏功能紊乱的情况外，纠正低钾血症不需要补充钾。建议使用β受体阻滞剂进行治疗，并对甲状腺功能亢进进行特异性治疗。
