Leather H A, Vuylsteke A, Bert C, M'Fam W, Segers P, Sergeant P, Vandermeersch E, Wouters P F
Department of Anaesthesiology, University Hospitals, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Anaesthesia. 2004 Apr;59(4):385-9. doi: 10.1111/j.1365-2044.2004.03668.x.
We evaluated a new, ultra-fast response continuous cardiac output monitor in 34 adult patients undergoing off-pump coronary artery bypass graft surgery. Cardiac output was measured with the TruCCOMS continuous cardiac output monitor (Aortech International plc, Lanarkshire, UK), using triplicate cold bolus thermodilution as the criterion standard, at fixed time points during surgery and during dobutamine infusion. The two techniques were compared using linear regression and Bland-Altman analysis. Overall, the study device displayed a bias of 0.4 l.min(-1) with limits of agreement of +2.5 l.min(-1) and -1.7 l.min(-1). The study device failed to detect the change in cardiac output caused by dobutamine accurately (y = 0.18x + 0.45; r(2) = 0.13), with an error linearly related to the magnitude of the change measured. We conclude that the device's failure to detect changes in cardiac output could be a major limitation in its clinical use in its current form.
我们对34例接受非体外循环冠状动脉搭桥手术的成年患者使用了一种新型的、超快速响应的连续心输出量监测仪。在手术期间及多巴酚丁胺输注期间的固定时间点,采用TruCCOMS连续心输出量监测仪(英国拉纳克郡Aortech International plc公司)测量心输出量,并将一式三份冷注射热稀释法作为标准对照。使用线性回归和Bland-Altman分析对这两种技术进行比较。总体而言,研究设备显示偏差为0.4 l.min(-1),一致性界限为+2.5 l.min(-1)和-1.7 l.min(-1)。研究设备未能准确检测到多巴酚丁胺引起的心输出量变化(y = 0.18x + 0.45;r(2) = 0.13),误差与所测变化幅度呈线性相关。我们得出结论,该设备无法检测心输出量变化可能是其当前形式临床应用中的一个主要限制。