González Rivera M, Pedromingo Marino A, Guardiola Pereira E, Bigorra Llosas J
Departamento Médico, Bayer Diagnósticos/Ames, Madrid.
Rev Clin Esp. 1992 Jul;191(3):156-60.
At the end of 1989 a transversal study to know the availability of glycosylated hemoglobin as a control parameter in diabetic patients was done. Two hundred and three physicians-specialists in diabetes-provided information on the fraction, technique and reference interval used in their clinical practice. 90 +/- 4% of the participants were able to obtain, in their settings, the determination of glycosylated hemoglobin. Regarding work-places it is outstanding that 36 +/- 15% of the physicians in primary care did not have the possibility to get this parameter determined. Fraction and technique more widely used were, respectively, HbA1 and Ionic Interchange Chromatography performed with HPLC. There was no homogeneity in the reference intervals for HbA1 and HbA1c, considering different methodologies. The possibility to obtain different glycosylated hemoglobin determined, depends on the setting where the health care is being provided. It is important to know the reference interval of the Center where the determination is being done, in order to correctly interpret the glycosylated hemoglobin values of each patient.
1989年底开展了一项横向研究，以了解糖化血红蛋白作为糖尿病患者控制参数的可用性。203名糖尿病专科医生提供了他们临床实践中使用的组分、技术和参考区间的信息。90±4%的参与者能够在其所在机构进行糖化血红蛋白的测定。关于工作场所，值得注意的是，36±15%的初级保健医生无法测定该参数。使用最广泛的组分和技术分别是HbA1和采用高效液相色谱法的离子交换色谱法。考虑到不同的方法，HbA1和HbA1c的参考区间并不统一。能否获得不同的糖化血红蛋白测定结果，取决于提供医疗服务的机构。为了正确解读每位患者的糖化血红蛋白值，了解进行测定的中心的参考区间很重要。
