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确定潜在器官捐献者:医院死亡情况审计

Identifying the potential organ donor: an audit of hospital deaths.

作者信息

Opdam Helen Ingrid, Silvester William

机构信息

Department of Intensive Care, Austin Hospital, Studley Road, 3084 Heidelberg, Victoria, Australia.

出版信息

Intensive Care Med. 2004 Jul;30(7):1390-7. doi: 10.1007/s00134-004-2185-9. Epub 2004 Mar 13.

Abstract

OBJECTIVE

To quantify the potential for organ donation in Victoria and identify missed opportunities for organ donation.

DESIGN AND SETTING

Prospective medical record audit of all deaths in 12 Victorian hospitals.

MEASUREMENTS

Data on deaths, total potential donors, organ donors and outcome of requests for organ donation were collected. Patients in whom brain death was confirmed or likely to occur and in whom organ donation was not requested (unrealised potential donors) were classified by an independent panel. Rates of organ donation and unrealised donors were determined as a proportion of total potential donors and hospital deaths and the maximal potential organ donor rate was estimated.

RESULTS

Of 5551 deaths, there were 112 potential donors, with 66 requests for organ donation resulting in 39 consents (consent rate of 59%) and 37 organ donors (33% of total potential donors; 0.7% of hospital deaths). Two consented potential donors did not donate due to failed physiological support (5%). There were 46 medically suitable unrealised potential donors; 3 with confirmed brain death. Approximately half of these patients had treatment withdrawn in the intensive care unit and half in the Emergency Department. The estimated maximal potential donor rate was 30 per million population.

CONCLUSIONS

The potential for organ donation in Victoria is relatively low compared with previous estimates in Australia and overseas. An increase in the organ donation rate may be possible through increasing consent and the identification and support of potential donors. This would require substantial changes in clinical practice that have resource and ethical implications.

摘要

目的

量化维多利亚州器官捐赠的潜力,并识别器官捐赠中错失的机会。

设计与背景

对维多利亚州12家医院所有死亡病例进行前瞻性病历审核。

测量指标

收集死亡、潜在捐赠者总数、器官捐赠者以及器官捐赠请求结果的数据。由一个独立小组对已确认或可能发生脑死亡但未被请求进行器官捐赠的患者(未实现的潜在捐赠者)进行分类。确定器官捐赠率和未实现捐赠者率,以占潜在捐赠者总数和医院死亡人数的比例表示,并估算最大潜在器官捐赠者率。

结果

在5551例死亡病例中,有112名潜在捐赠者,66例器官捐赠请求中有39例获得同意(同意率为59%),37名器官捐赠者(占潜在捐赠者总数的33%;占医院死亡人数的0.7%)。两名同意捐赠的潜在捐赠者因生理支持失败未进行捐赠(5%)。有46名医学上合适的未实现潜在捐赠者;3例已确认脑死亡。这些患者中约一半在重症监护病房停止治疗,另一半在急诊科停止治疗。估计最大潜在捐赠者率为每百万人口30例。

结论

与澳大利亚和海外先前的估计相比,维多利亚州的器官捐赠潜力相对较低。通过提高同意率以及识别和支持潜在捐赠者,可能提高器官捐赠率。这将需要临床实践发生重大改变,这涉及资源和伦理问题。

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