聚脱氧核糖核苷酸在自体皮肤移植供区愈合过程中的疗效评估：一项初步研究。
Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study.
作者信息
Valdatta Luigi, Thione Alessandro, Mortarino Christian, Buoro Mara, Tuinder Stefania
机构信息
Plastic Surgery Unit, University of Insubria, Ospedale di Circolo-Fondazione Macchi, Varese, Italy.
出版信息
Curr Med Res Opin. 2004 Mar;20(3):403-8. doi: 10.1185/030079904125003116.
OBJECTIVE
The article presents the results of a pilot study performed to evaluate the efficacy of polydeoxyribonucleotides (PDRNs) in shortening the healing times of autologous skin graft donor sites. RESEARCH DESIGN, METHODS: Two groups of patients were studied, the PDRN group (n = 20) and a control group (n = 20). In the control group dressings were performed with non-adherent gauzes and bulky gauzes with cloramine solution, whereas in the PDRN group a PDRN ointment was spread under the same medication as the controls.
RESULTS
In the PDRN group, dressing procedures were not painful (whereas in the controls they often were), re-epithelialisation occurred earlier (12.5 vs 24.45 days) and there were no infections (9 in the controls).
CONCLUSIONS
Results are encouraging for the use of PDRNs in shortening the healing times of autologous skin graft donor sites, although further studies are necessary to obtain clinically relevant results.
目的
本文介绍了一项初步研究的结果，该研究旨在评估聚脱氧核糖核苷酸（PDRN）在缩短自体皮肤移植供区愈合时间方面的疗效。研究设计、方法：对两组患者进行了研究，PDRN组（n = 20）和对照组（n = 20）。对照组使用非粘性纱布和含氯胺溶液的厚纱布进行换药，而PDRN组在与对照组相同的药物治疗下涂抹PDRN软膏。
结果
在PDRN组中，换药过程不疼痛（而对照组经常疼痛），上皮再形成更早出现（12.5天对24.45天），且无感染发生（对照组有9例感染）。
结论
尽管需要进一步研究以获得临床相关结果，但PDRN在缩短自体皮肤移植供区愈合时间方面的应用结果令人鼓舞。
Zotero 插件