Luppi B, Cerchiara T, Bigucci F, Basile R, Zecchi V
Department of Pharmaceutical Sciences, Bologna University, Via San Donato 19/2, 40127 Bologna, Italy.
J Pharm Pharmacol. 2004 Mar;56(3):407-11. doi: 10.1211/0022357022926.
Benzophenone-3 (BZP) or oxybenzone is widely used in many cosmetic formulations, such as sunscreen lotions or emulsions, shampoos and hair sprays. The nature of the vehicle used can enhance or block the percutaneous absorption of UV filter. In this work, we hydrophobically modified polyvinylalcohol 10 000 (PVA) with fatty acids (FAs) to obtain PVA-FA derivatives for the preparation of lipophilic polymeric nanoparticles able to prevent BZP movement towards the skin. Synthesized PVA-FA derivatives were confirmed by H1 NMR. Nanoparticles loaded with BZP were prepared using a solvent extraction method. The particle size was monitored by means of dynamic light scattering measurements. In-vitro skin permeation studies were performed.
二苯甲酮-3（BZP）或二苯甲酰甲烷广泛应用于许多化妆品配方中，如防晒乳液或乳剂、洗发水和发胶。所使用载体的性质可以增强或阻碍紫外线过滤剂的经皮吸收。在这项工作中，我们用脂肪酸（FAs）对聚乙烯醇10000（PVA）进行疏水改性，以获得PVA-FA衍生物，用于制备能够防止BZP向皮肤移动的亲脂性聚合物纳米颗粒。通过核磁共振氢谱（H1 NMR）确认了合成的PVA-FA衍生物。采用溶剂萃取法制备了负载BZP的纳米颗粒。通过动态光散射测量监测粒径。进行了体外皮肤渗透研究。
