几内亚比绍结核分枝杆菌复合群菌株家族的基因特征分析。
Genetic characterization of the Guinea-Bissau family of Mycobacterium tuberculosis complex strains.
作者信息
Koivula Tuija, Ekman Martin, Leitner Thomas, Löfdahl Sven, Ghebremicahel Solomon, Mostowy Serge, Behr Marcel A, Svenson Stefan B, Källenius Gunilla
机构信息
Swedish Institute for Infectious Disease Control, 17182 Solna, Sweden.
出版信息
Microbes Infect. 2004 Mar;6(3):272-8. doi: 10.1016/j.micinf.2003.12.006.
In a previous study of Mycobacterium tuberculosis complex isolates from Guinea-Bissau in West Africa, we identified a unique group of strains, designated here as the Guinea-Bissau family of strains, which, although genotypically closely related, phenotypically demonstrated a considerable heterogeneity. We conducted here a detailed genotypic analysis of a subset (n = 35) of these isolates. Based on the data obtained, and by comparison of known corresponding genes in mycobacteria outside the M. tuberculosis complex, we propose that the Guinea-Bissau strains belong to a unique branch of the M. tuberculosis complex tree in between classical M. tuberculosis and classical M. bovis. These observations are discussed in their significance in M. tuberculosis complex classification.
在之前一项针对西非几内亚比绍结核分枝杆菌复合群分离株的研究中，我们鉴定出了一组独特的菌株，在此将其命名为几内亚比绍菌株家族。这些菌株虽然在基因型上密切相关，但在表型上表现出相当大的异质性。我们在此对这些分离株的一个子集（n = 35）进行了详细的基因型分析。根据所获得的数据，并通过与结核分枝杆菌复合群之外的分枝杆菌中已知的相应基因进行比较，我们提出几内亚比绍菌株属于结核分枝杆菌复合群树中位于经典结核分枝杆菌和经典牛分枝杆菌之间的一个独特分支。我们讨论了这些观察结果在结核分枝杆菌复合群分类中的意义。
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