Piédrola Angulo Gonzalo
An R Acad Nac Med (Madr). 2003;120(3):409-19; discussion 419-25.
The possibility of a colonization and later urinary infection is due to a first contact among a series of structures of the bacterium, denominated adhesins (fimbrica or no-fimbrica) and some receivers or ligands of the surface of the urinary epitelium. The bacterial fimbriae of Escherichia coli, of those that have been studied up to seven different types, are protean structures coded by the chromosomal DNA, being the most important those of type 1, in connection with the colonization of the low roads, and the type P, with the cystitis and pyelonephritis. They are studied with detail their different protean components and the very complex genetic regulation of their production, made of great interest in the pathogeny of these infections and in the possibility of their prevention. The receivers of each fimbriae type are also chemically different, and their knowledge would explain important clinical data.
细菌定植并随后引发泌尿系统感染的可能性，是由于细菌的一系列结构（称为黏附素，有菌毛或无菌毛）与尿路上皮表面的一些受体或配体首次接触所致。已研究的大肠杆菌菌毛多达七种不同类型，它们是由染色体DNA编码的多变结构，其中1型菌毛对于下尿路定植最为重要，P型菌毛与膀胱炎和肾盂肾炎有关。人们详细研究了它们不同的多变成分及其产生过程中非常复杂的基因调控，这对这些感染的发病机制以及预防可能性具有极大的研究价值。每种菌毛类型的受体在化学性质上也各不相同，了解它们有助于解释重要的临床数据。
