Maroto Vela Ma del Carmen
An R Acad Nac Med (Madr). 2003;120(3):427-41; discussion 442-8.
The main characteristics of the genome of the virus of the hepatitis C is studied, especially those such parts as the IRES for its capacity of union to the ribosome of the cell, the HVR1 for its high capacity of viral replication, as well as the place of union to the PKR or the ISDR, inside the protein NS5. They are defined the genotype concepts, subtype and quasispecies, and their implications in different such aspects as: 1) pathogenicity (in the severity of the infectious process, in the extrahepatic manifestations and in the appearance of the hepatocarcinoma); 2) in the biggest or smaller sensibility in the diagnostic techniques; 3) in the resistance to the treatment with interferon (well through the road NS3 or NS5, so much through the changes in PKR or the mutations in ISDR), and 4) in the epidemiology (changes of geographical variability, use of that variability like epidemic marker and obtaining difficulty of vaccines).
对丙型肝炎病毒基因组的主要特征进行了研究，特别是诸如内部核糖体进入位点（IRES）因其与细胞核糖体结合的能力、高变区1（HVR1）因其高病毒复制能力，以及在NS5蛋白内与蛋白激酶R（PKR）或干扰素刺激反应元件（ISDR）结合位点等部分。定义了基因型、亚型和准种的概念，以及它们在不同方面的影响，如：1）致病性（在感染过程的严重程度、肝外表现和肝癌的出现方面）；2）在诊断技术中的敏感性高低；3）对干扰素治疗的耐药性（通过NS3或NS5途径，以及通过PKR的变化或ISDR中的突变），以及4）在流行病学方面（地理变异性的变化、将该变异性用作流行标志物以及疫苗获取的困难程度）。
