Virology Department, Amiens University Hospital Center, South Hospital, Amiens, France.
J Viral Hepat. 2011 Feb;18(2):77-83. doi: 10.1111/j.1365-2893.2010.01367.x. Epub 2010 Sep 6.
Genetic recombination is a well-known feature of RNA viruses that plays a significant role in their evolution. Although recombination is well documented for Flaviviridae family viruses, the first natural recombinant strain of hepatitis C virus (HCV) was identified as recently as 2002. Since then, a few other natural inter-genotypic, intra-genotypic and intra-subtype recombinant HCV strains have been described. However, the frequency of recombination may have been underestimated because not all known HCV recombinants are screened for in routine practice. Furthermore, the choice of treatment regimen and its predictive outcome remain problematic as the therapeutic strategy for HCV infection is genotype dependent. HCV recombination also raises many questions concerning its mechanisms and effects on the epidemiological and physiopathological features of the virus. This review provides an update on recombinant HCV strains, the process that gives rise to recombinants and clinical implications of recombination.
遗传重组是 RNA 病毒的一个众所周知的特征，在其进化中起着重要作用。尽管 Flaviviridae 科病毒的重组有充分的记录，但直到 2002 年才首次鉴定出丙型肝炎病毒 (HCV) 的天然重组株。从那时起，已经描述了其他几种天然的基因型间、基因型内和亚基因型内的 HCV 重组株。然而，由于并非所有已知的 HCV 重组体都在常规实践中进行筛选，因此重组的频率可能被低估了。此外，由于 HCV 感染的治疗策略取决于基因型，因此治疗方案的选择及其预测结果仍然存在问题。HCV 重组也引发了许多关于其机制及其对病毒的流行病学和生理病理特征的影响的问题。这篇综述提供了关于重组 HCV 株、产生重组体的过程以及重组的临床意义的最新信息。
