Bell S L, Thomas R J
Department of Agriculture, University of Newcastle upon Tyne, UK.
Vet Parasitol. 1992 Mar;41(3-4):233-9. doi: 10.1016/0304-4017(92)90083-l.
The effectiveness of albendazole in a controlled-release bolus in controlling gastrointestinal nematodes in lambs was assessed during the summer of 1986. Faecal egg counts were almost entirely negative throughout in the treated group and larval challenge remained low at below 2000 larvae kg-1. Untreated control lambs showed a characteristic pattern of auto-infection, culminating in a peak pasture larval count of over 70,000 larvae kg-1 and an outbreak of parasitic gastroenteritis in September associated with a serum pepsinogen concentration of 1.183 IU tyrosine and a mean worm burden of 91,165 nematodes at necropsy, including Ostertagia, Trichostrongylus and Nematodirus species. Subject to the restrictions imposed by the size of the bolus, this was considered to be a highly effective method of seasonal parasite control.
1986年夏季，对阿苯达唑控释丸剂控制羔羊胃肠道线虫的效果进行了评估。在整个治疗期间，治疗组的粪便虫卵计数几乎完全为阴性，幼虫感染率一直较低，低于2000条幼虫/千克。未治疗的对照羔羊表现出典型的自身感染模式，最终牧场幼虫计数峰值超过70000条幼虫/千克，并在9月爆发了寄生性胃肠炎，尸检时血清胃蛋白酶原浓度为1.183 IU酪氨酸，平均蠕虫负荷为91165条线虫，包括奥斯特他线虫、毛圆线虫和细颈线虫属。在丸剂大小所施加的限制条件下，这被认为是一种非常有效的季节性寄生虫控制方法。
