Walker Lucy S K
MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.
Immunology. 2004 Feb;111(2):129-37. doi: 10.1111/j.0019-2805.2003.01788.x.
Research on CD4+ CD25+ regulatory T cells (Treg) has gathered momentum over the last five years but many aspects of their fundamental biology remain elusive. Treg have been considered to be 'naturally anergic' based on their failure to proliferate in response to T-cell receptor ligation in vitro. Several recent studies challenge this view and demonstrate a robust proliferative capacity for CD25+ cells. The significance of this finding for Treg homeostasis and function is considered below.
在过去五年中，关于CD4+ CD25+调节性T细胞（Treg）的研究发展迅速，但它们基本生物学的许多方面仍然难以捉摸。基于Treg在体外对T细胞受体连接反应中无法增殖，它们一直被认为是“天然无反应性的”。最近的几项研究对这一观点提出了挑战，并证明CD25+细胞具有强大的增殖能力。这一发现对Treg稳态和功能的意义将在下文讨论。
