膜融合：陷入困境。

Membrane fusion: caught in a trap.

作者信息

Short Benjamin, Barr Francis A

机构信息

Department of Cell Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152 Germany.

出版信息

Curr Biol. 2004 Mar 9;14(5):R187-9. doi: 10.1016/j.cub.2004.02.017.

DOI:10.1016/j.cub.2004.02.017

PMID:15028233

Abstract

SNAREs are small coiled-coil proteins required for specific membrane fusion events in eukaryotic cells. Recent evidence points to the existence of an inhibitory class of SNAREs, i-SNAREs, which prevent incorrect fusions from occurring, adding a further layer of regulation to the process of membrane docking and fusion.

摘要

SNARE蛋白是真核细胞中特定膜融合事件所必需的小的卷曲螺旋蛋白。最近的证据表明存在一类抑制性SNARE蛋白，即i-SNARE蛋白，它们可防止错误融合的发生，为膜对接和融合过程增添了另一层调控。