多亚基连接复合物及其在膜融合中的作用。

Multisubunit tethering complexes and their role in membrane fusion.

机构信息

University of Osnabrück, Department of Biology/Chemistry, Barbarastrasse 13, 49076 Osnabrück, Germany.

出版信息

Curr Biol. 2010 Nov 9;20(21):R943-52. doi: 10.1016/j.cub.2010.09.015.

DOI:10.1016/j.cub.2010.09.015

Abstract

Protein trafficking within eukaryotic cells depends on vesicular carriers that fuse with organelles to deliver their lipid and protein content. Cells have developed an elaborate system to capture vesicles at organelles that involves the action of Rab GTPases and tethers. Vesicle fusion then takes place with the help of SNARE proteins. In this review we focus on the role of multisubunit tethering complexes of eukaryotic cells. In particular, we discuss the tethering complexes of the secretory pathway and the endolysosomal system and highlight recent evidence for the role of these complexes in interaction with Rabs, coat recognition and cooperation with SNAREs during the fusion cascade.

摘要

真核细胞内的蛋白质运输依赖于囊泡载体，这些载体与细胞器融合以输送其脂质和蛋白质内容物。细胞已经开发出一种精细的系统来捕获细胞器处的囊泡，其中涉及 Rab GTPases 和 tether 的作用。囊泡融合然后在 SNARE 蛋白的帮助下发生。在这篇综述中，我们专注于真核细胞多亚基 tethering 复合物的作用。特别是，我们讨论了分泌途径和内体溶酶体系统的 tethering 复合物，并强调了这些复合物在与 Rab、coat 识别以及与 SNARE 合作以进行融合级联反应中的作用的最新证据。