Lyubimova N V, Beyshembaev A M, Kushlinskiy D N, Zordania K I, Adamyan L V
N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2011 Mar;150(5):635-8. doi: 10.1007/s10517-011-1209-z.
We present the results of immunoenzyme detection of inhibin B in blood serum of patients with adult-type granulosa cell tumors of the ovary. Blood concentration of inhibin B at the end of menstrual cycle in patients with tumor relapse was significantly higher than in patients during remission and in virtually healthy women. The increase in inhibin B concentration preceded clinical manifestation of the disease relapse by 2-13 months, which demonstrates high diagnostic sensitivity of this marker and suggests that it can be recommended for the use in diagnostics and monitoring of granulosa cell tumors of the ovaries.
我们展示了卵巢成人型颗粒细胞瘤患者血清中抑制素B的免疫酶检测结果。肿瘤复发患者月经周期结束时血清中抑制素B的浓度显著高于缓解期患者和几乎健康的女性。抑制素B浓度升高比疾病复发的临床表现提前2 - 13个月，这表明该标志物具有高诊断敏感性，并建议可将其用于卵巢颗粒细胞瘤的诊断和监测。
