Rey R A, Lhommé C, Marcillac I, Lahlou N, Duvillard P, Josso N, Bidart J M
Institut National de la Santé et de la Recherche Médicale, Montrouge, France.
Am J Obstet Gynecol. 1996 Mar;174(3):958-65. doi: 10.1016/s0002-9378(96)70333-2.
Our purpose was to evaluate serum antimüllerian hormone as a marker for granulosa cell tumors.
Serum antimüllerian hormone concentrations were determined in 16 patients with an adult-type granulosa cell tumor; in female patients with ovarian adenocarcinoma, benign ovarian cysts, or extraovarian cancers; and in normal premenopausal and postmenopausal women. Serum antimüllerian hormone, alpha-inhibin, and estradiol levels were compared in 10 patients with a granulosa cell tumor during 6 to 47 months of follow-up.
Serum antimüllerian hormone was undetectable in normal postmenopausal women and was <5 micrograms/L in premenopausal women. Normal serum levels were found in patients with ovarian cancers or cysts or with extraovarian cancers. Levels were between 6.8 and 117.9 microg/L in eight of nine patients with a progressive granulosa cell tumor. In the remaining case antimüllerian hormone, alpha-inhibin and estradiol concentrations were normal. Serum antimüllerian hormone and alpha-inhibin levels became elevated at least 11 months before the recurrence was clinically detectable. During clinical remission serum antimullerian hormone, beta-inhibin, and estradiol were normal in most cases.
Serum antimüllerian hormone is a sensitive, specific, reliable marker of adult-type granulosa cell tumors and is useful to evaluate the efficacy of treatment and to detect recurrences early.
我们的目的是评估血清抗苗勒管激素作为颗粒细胞瘤标志物的价值。
测定了16例成年型颗粒细胞瘤患者、卵巢腺癌女性患者、良性卵巢囊肿女性患者、卵巢外癌症女性患者以及正常绝经前和绝经后女性的血清抗苗勒管激素浓度。对10例颗粒细胞瘤患者在6至47个月的随访期间的血清抗苗勒管激素、α-抑制素和雌二醇水平进行了比较。
正常绝经后女性血清中未检测到抗苗勒管激素，绝经前女性血清抗苗勒管激素浓度<5微克/升。卵巢癌、囊肿或卵巢外癌症患者的血清水平正常。9例进展性颗粒细胞瘤患者中有8例的抗苗勒管激素水平在6.8至117.9微克/升之间。其余病例中抗苗勒管激素、α-抑制素和雌二醇浓度正常。血清抗苗勒管激素和α-抑制素水平在临床可检测到复发前至少11个月升高。在临床缓解期，大多数病例的血清抗苗勒管激素、β-抑制素和雌二醇水平正常。
血清抗苗勒管激素是成年型颗粒细胞瘤敏感、特异、可靠的标志物，有助于评估治疗效果并早期检测复发。
