Yilmaz Mehmet Birhan, Akin Yesim, Biyikoglu Senay Funda, Guray Umit, Kisacik Halil L, Korkmaz Sule
Yuksek Ihtisas Hospital, Cardiology Clinic, Sihhiye, Ankara, Turkey.
Acta Cardiol. 2004 Feb;59(1):41-5. doi: 10.2143/AC.59.1.2005157.
Dilated cardiomyopathy has been associated with left ventricular thrombosis, which leads to substantial morbidity and mortality as a site for peripheral emboli. There are some studies on patients with dilated cardiomyopathy showing altered haemostasis and platelet behaviour despite sinus rhythm. Mean platelet volume, which is the most accurate and simple estimate of platelet reactivity, may be associated with the development of left ventricular thrombosis.
We prospectively enrolled 48 consecutive patients with dilated cardiomyopathy and sinus rhythm with left ventricular thrombosis and compared them with an age-sex-matched control group having dilated cardiomyopathy without left ventricular thrombosis. We found that in patients with left ventricular thrombosis mean platelet volume is significantly higher than those without (9.5 +/- 0.8 vs. 8.7 +/- 0.6, p < 0.001).
Mean platelet volume is increased in patients with dilated cardiomyopathy and sinus rhythm having left ventricular thrombosis. This might be reflecting a causal relationship, which in turn requires further study to establish the role of antiplatelet agents both in prevention and in treatment.
扩张型心肌病与左心室血栓形成有关，左心室血栓作为外周栓子的来源可导致严重的发病率和死亡率。有一些针对扩张型心肌病患者的研究表明，尽管患者为窦性心律，但止血功能和血小板行为仍发生了改变。平均血小板体积是对血小板反应性最准确、最简单的评估指标，可能与左心室血栓形成有关。
我们前瞻性地连续纳入了48例患有扩张型心肌病且为窦性心律并伴有左心室血栓形成的患者，并将他们与年龄和性别匹配的无左心室血栓形成的扩张型心肌病对照组进行比较。我们发现，有左心室血栓形成的患者平均血小板体积显著高于无左心室血栓形成的患者（9.5±0.8对8.7±0.6，p<0.001）。
患有扩张型心肌病且为窦性心律并伴有左心室血栓形成的患者平均血小板体积增加。这可能反映了一种因果关系，反过来需要进一步研究以确定抗血小板药物在预防和治疗中的作用。
