Department of Cardiology, Bozok University Faculty of Medicine, Yozgat, Turkey.
Angiology. 2012 Oct;63(7):552-5. doi: 10.1177/0003319711435146. Epub 2012 Feb 1.
We assessed the clinical echocardiograhic, hematological, and biochemical parameters in patients with dilated cardiomyopathy (DCMP) and control individuals mainly focusing on the mean platelet volume (MPV) in terms of DCMP and left ventricle (LV) thrombus formation. Consecutive patients (n = 251) with DCMP and 266 patients without DCMP were studied. Mean platelet volume was significantly greater in patients with DCMP than in control patients (P < .05 for all comparisons). Comparing DCMP patients with LV thrombus (19 patients, 8%) and without LV thrombus (232 patients, 92%) showed that the prevalence of smokers was significantly higher and ejection fraction was significantly lower in patients with LV thrombus. We have shown that patients with DCMP have significantly higher MPV suggesting more platelet activation and the MPV of patients with DCMP and LV thrombus is comparable to those of patients without LV thrombus.
我们评估了扩张型心肌病（DCMP）患者和对照组个体的临床超声心动图、血液学和生化学参数，主要关注血小板平均体积（MPV）与 DCMP 和左心室（LV）血栓形成的关系。研究了连续的 251 例 DCMP 患者和 266 例无 DCMP 患者。与对照组患者相比，DCMP 患者的血小板平均体积明显更大（所有比较均 P <.05）。比较伴有 LV 血栓形成的 DCMP 患者（19 例，8%）和无 LV 血栓形成的患者（232 例，92%）显示，LV 血栓形成患者中吸烟者的比例明显更高，射血分数明显更低。我们已经表明，DCMP 患者的血小板平均体积明显更高，提示血小板活化程度更高，且伴有 LV 血栓形成的 DCMP 患者的血小板平均体积与无 LV 血栓形成的患者相当。
