秋水仙碱过量继发中毒性表皮坏死松解症样反应。
Toxic epidermal necrolysis-like reaction secondary to colchicine overdose.
作者信息
Arroyo M P, Sanders S, Yee H, Schwartz D, Kamino H, Strober B E
机构信息
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA.
出版信息
Br J Dermatol. 2004 Mar;150(3):581-8. doi: 10.1111/j.1365-2133.2004.05838.x.
Colchicine is a microtubule-inhibiting drug used to treat gout, familial Mediterranean fever and many other skin diseases. Intoxication with colchicine affects multiple organs, often fatally. Cutaneous sequelae of colchicine toxicity are rare. We describe the clinical and histological features of a toxic epidermal necrolysis-like exanthem in a patient who lethally overdosed on colchicine.
秋水仙碱是一种微管抑制药物，用于治疗痛风、家族性地中海热和许多其他皮肤病。秋水仙碱中毒会影响多个器官，常导致致命后果。秋水仙碱毒性的皮肤后遗症较为罕见。我们描述了一名因过量服用秋水仙碱致死的患者出现中毒性表皮坏死松解样皮疹的临床和组织学特征。
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