Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.
Critical Care Complex, Middlemore Hospital, Auckland, New Zealand.
Rheumatology (Oxford). 2024 Apr 2;63(4):936-944. doi: 10.1093/rheumatology/kead625.
Colchicine has an important role in managing various conditions, including gout, familial Mediterranean fever, amyloidosis, Behçet's syndrome, recurrent pericarditis and calcium pyrophosphate deposition disease. The adverse effect profile of colchicine is well understood. However, due to its narrow therapeutic index, colchicine has been associated with overdose and fatalities. When ingested in toxic amounts, the mainstay of management is supportive care. Strategies to minimize the risk of colchicine poisoning can focus on three broad causes: unauthorized access, intentional overdose and inappropriate dosing. Culturally safe and appropriate education about storage and appropriate use of colchicine is essential to minimize the risk of overdose.
秋水仙碱在治疗多种疾病方面具有重要作用，包括痛风、家族性地中海热、淀粉样变性、贝切特综合征、复发性心包炎和焦磷酸钙沉积病。秋水仙碱的不良反应谱已经得到充分了解。然而，由于其治疗指数较窄，秋水仙碱与过量用药和死亡相关。当摄入有毒量时，主要的治疗方法是支持性护理。减少秋水仙碱中毒风险的策略可以集中在三个广泛的原因上：未经授权的获取、故意过量用药和不适当的剂量。关于秋水仙碱的储存和正确使用的文化上安全且合适的教育对于降低用药过量的风险至关重要。
