Boucher Philippe, Gotthardt Michael
Philippe Boucher is at the Department of Pharmacology, University of Strasbourg, Strasbourg, France.
Trends Cardiovasc Med. 2004 Feb;14(2):55-60. doi: 10.1016/j.tcm.2003.12.001.
The low-density lipoprotein (LDL) receptor-related protein (LRP) is a member of the LDL receptor family. In addition to its role in endocytosis and uptake of multiple ligands, it is now apparent that LRP, like some other members of the family, is also involved in signal transduction. Through LRP, both endocytosis and signaling coexist at the surface of the plasma membrane and regulate critical cellular physiology and signal transduction events. This article focuses on the recently uncovered molecular mechanisms by which LRP, its ligand apolipoprotein E, and the platelet-derived growth factor receptor cooperate in the remodeling of the vascular wall and protect against atherosclerosis.
低密度脂蛋白（LDL）受体相关蛋白（LRP）是LDL受体家族的成员。除了在多种配体的内吞作用和摄取中发挥作用外，现在很明显，LRP与该家族的其他一些成员一样，也参与信号转导。通过LRP，内吞作用和信号转导在质膜表面共存，并调节关键的细胞生理和信号转导事件。本文重点关注最近发现的分子机制，即LRP、其配体载脂蛋白E和血小板衍生生长因子受体在血管壁重塑中协同作用并预防动脉粥样硬化。
