Zaczek Anna, Laurell Carl-Gustaf, Zetterström Charlotta
St. Erik's Eye Hospital, Stockholm, Sweden.
J Cataract Refract Surg. 2004 Feb;30(2):316-20. doi: 10.1016/j.jcrs.2003.07.006.
To evaluate the effect of dexamethasone, diclofenac, and a placebo given for 3 weeks after phacoemulsification and intraocular lens (IOL) implantation on the formation of posterior capsule opacification (PCO).
St. Erik's Eye Hospital, Stockholm, Sweden.
In a 2-year prospective randomized double-blind study, a laser flare meter was used to measure aqueous flare intensity preoperatively and 3 days, 2 weeks, and 2 years after phacoemulsification and IOL implantation. Posterior capsule opacification was evaluated 2 years postoperatively using retroillumination images taken with a Scheimpflug camera. The Evaluation of Posterior Capsule Opacification system was used to score the areas of PCO density.
The median rate of PCO 2 years after phacoemulsification was 0.72 (range 0.32 to 1.57) in the dexamethasone group, 0.78 (range 0.19 to 2.14) in the diclofenac group, and 0.70 (range 0.35 to 1.70) in the placebo group. The differences were not statistically significant (P>.05; Kruskal-Wallis analysis of variance, multiple comparisons). The rate of neodymium:YAG laser posterior capsulotomy during the 2 years after surgery was not statistically different between groups (P>.05, chi-square test). There was no correlation (Spearman rank coefficient) between laser flare measurements and PCO formation in any group during the study (P>.05).
Topical instillation of diclofenac, dexamethasone, or a placebo in the immediate period after phacoemulsification and IOL implantation did not seem to influence the formation of PCO 2 years after cataract surgery.
评估白内障超声乳化吸除联合人工晶状体（IOL）植入术后给予地塞米松、双氯芬酸和安慰剂3周对后囊膜混浊（PCO）形成的影响。
瑞典斯德哥尔摩圣埃里克眼科医院。
在一项为期2年的前瞻性随机双盲研究中，使用激光散射仪在术前以及白内障超声乳化吸除联合IOL植入术后3天、2周和2年测量房水闪光强度。术后2年使用Scheimpflug相机拍摄的后照光图像评估后囊膜混浊情况。采用后囊膜混浊评估系统对PCO密度区域进行评分。
地塞米松组白内障超声乳化吸除术后2年PCO的中位数为0.72（范围0.32至1.57），双氯芬酸组为0.78（范围0.19至2.14），安慰剂组为0.70（范围0.35至1.70）。差异无统计学意义（P>0.05；Kruskal-Wallis方差分析，多重比较）。术后2年内钕:钇铝石榴石激光后囊膜切开术的发生率在各组之间无统计学差异（P>0.05，卡方检验）。在研究期间，任何一组的激光闪光测量值与PCO形成之间均无相关性（Spearman等级系数）（P>0.05）。
白内障超声乳化吸除联合IOL植入术后立即局部滴注双氯芬酸、地塞米松或安慰剂似乎不影响白内障手术后2年PCO的形成。
