Planas M, Conde M, Audivert S, Pérez-Portabella C, Burgos R, Chacón P, Rossello J, Boada M, Tàrraga L L
Nutritional Support Unit, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona 08035, Spain.
Clin Nutr. 2004 Apr;23(2):265-72. doi: 10.1016/S0261-5614(03)00106-7.
To evaluate if nutritional supplementation with or without micronutrient enhancement prevent weight loss and the progression of the disease in mild Alzheimer's Disease (AD) patients.
Mild AD patients were recruited from an Alzheimer Day Centre. Subjects received oral liquid supplements with (Study-group: S) or without (Control-group: C) micronutrient enhancement. Intake assessment, nutritional status, biochemical parameters, cognitive function, and eating behaviour disorders were determined at baseline and at 6 months of treatment.
At baseline both groups were not different in any variable measured. They were norm nourished, with normal biochemical parameters. Blandford scale demonstrated a mild alteration of feeding behaviour, the cognitive scale classified the patients as impaired and there was presence of memory complaints. After 6 months of nutritional supplements, a similar increase in energy consumption was observed in both groups of patients (P<0.05). In the within-group analysis, we found a trend (P=0.05) to increase body mass index; a significant increase in triceps skin fold thickness, mid-upper-arm circumference and serum magnesium, zinc and selenium, and a significant reduction in serum vitamin E (P<0.001, each). Serum cholesterol decreased substantially only in the S-group (P=0.025). No significant differences at baseline, within-group, neither between-group analysis in feeding behaviour nor in cognitive function were observed.
According to our results no benefits in the progression of the disease was observed with micronutrient enhancement supplements. Effectiveness of nutritional supplements in preventing weight loss in mild AD patients showed a similar behaviour as observed in other populations. Due to the beneficial evolution of serum cholesterol in the S-group, this intervention deserves further investigation.
评估补充营养（无论是否添加微量营养素强化剂）能否预防轻度阿尔茨海默病（AD）患者体重减轻及疾病进展。
从一家老年痴呆日间护理中心招募轻度AD患者。受试者接受添加（研究组：S）或未添加（对照组：C）微量营养素强化剂的口服液体补充剂。在基线期和治疗6个月时测定摄入量评估、营养状况、生化参数、认知功能和饮食行为障碍。
在基线期，两组在任何测量变量上均无差异。他们营养状况正常，生化参数正常。布兰德福德量表显示进食行为有轻度改变，认知量表将患者分类为受损，且存在记忆障碍主诉。营养补充6个月后，两组患者的能量消耗均有类似增加（P<0.05）。在组内分析中，我们发现体重指数有增加趋势（P=0.05）；肱三头肌皮褶厚度、上臂中部周长以及血清镁、锌和硒显著增加，血清维生素E显著降低（均P<0.001）。仅S组的血清胆固醇大幅下降（P=0.025）。在基线期、组内以及组间分析中，进食行为和认知功能均未观察到显著差异。
根据我们的结果，添加微量营养素强化剂的补充剂在疾病进展方面未显示出益处。营养补充剂在预防轻度AD患者体重减轻方面的有效性与在其他人群中观察到的情况相似。由于S组血清胆固醇的有益变化，这种干预值得进一步研究。
