Franzoni Ferdinando, Scarfò Giorgia, Guidotti Sara, Fusi Jonathan, Asomov Muzaffar, Pruneti Carlo
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Department of Medicine and Surgery, University of Parma, Parma, Italy.
Front Neurosci. 2021 Oct 13;15:729757. doi: 10.3389/fnins.2021.729757. eCollection 2021.
Free- radicals (Oxygen and Nitrogen species) are formed in mitochondria during the oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an increase of the oxidative stress. This condition affects above all the brain, that usually needs a large oxygen amount and in which there is the major possibility to accumulate "Reacting Species." Antioxidant molecules are fundamental in limiting free-radical damage, in particular in the central nervous system: the oxidative stress, in fact, seems to worsen the course of neurodegenerative diseases. The aim of this review is to sum up natural antioxidant molecules with the greatest neuroprotective properties against free radical genesis, understanding their relationship with the Central Nervous System.
自由基（氧和氮类物质）在氧化磷酸化过程中于线粒体中形成。由于存在未配对电子，它们具有高反应活性，会导致氧化应激增加。这种情况首先会影响大脑，因为大脑通常需要大量氧气，且最有可能积累“反应性物质”。抗氧化分子对于限制自由基损伤至关重要，尤其是在中枢神经系统中：事实上，氧化应激似乎会使神经退行性疾病的病情恶化。本综述的目的是总结具有最强神经保护特性、可对抗自由基生成的天然抗氧化分子，了解它们与中枢神经系统的关系。
