Schwartz J M, Aylward E, Barta P E, Tune L E, Pearlson G D
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Am J Psychiatry. 1992 Sep;149(9):1195-8. doi: 10.1176/ajp.149.9.1195.
Since previous work indicated smaller than normal temporal lobe structures in schizophrenic patients, the authors tested the hypothesis that this abnormality might be reflected in abnormally large sylvian fissures.
The subjects were 48 schizophrenic patients and 51 normal comparison subjects matched groupwise with regard to age and sex. CSF spaces (sylvian fissures, temporal lobe sulci, temporal horns, third ventricle, lateral ventricles, and superficial cerebral sulci) were visually assessed with the magnetic resonance imaging rating protocol of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD).
The sylvian fissures of the schizophrenic patients were found to be bilaterally wider than those of the comparison subjects. There were no other significant differences.
Schizophrenic patients appear to have larger than normal sylvian fissures, which may reflect smaller superior temporal gyri.
鉴于先前的研究表明精神分裂症患者的颞叶结构小于正常水平，作者检验了这样一种假设，即这种异常可能反映在大脑外侧裂异常增宽上。
研究对象为48例精神分裂症患者和51名正常对照者，两组在年龄和性别上进行了匹配。使用阿尔茨海默病注册协会（CERAD）的磁共振成像评分方案对脑脊液间隙（大脑外侧裂、颞叶沟、颞角、第三脑室、侧脑室和大脑浅表沟）进行视觉评估。
发现精神分裂症患者的大脑外侧裂双侧比对照者宽。没有其他显著差异。
精神分裂症患者似乎有大于正常的大脑外侧裂，这可能反映了颞上回较小。
