Videbech Poul, Ravnkilde Barbara, Gammelgaard Lise, Egander Annette, Clemmensen Karin, Rasmussen Niels Anton, Gjedde Albert, Rosenberg Raben
Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Psychiatric Hospital, Aarhus University Hospitals, DK-8240 Risskov, Denmark.
Psychiatry Res. 2004 Feb 15;130(2):117-30. doi: 10.1016/j.pscychresns.2003.10.002.
The Stroop test (ST) assesses the integrity of prefrontal and cingulate functioning. Patients with major depression perform poorly on the ST, pointing to disturbed function in these areas. We therefore used positron emission tomography to study 41 in-patients with major depression and 46 age- and gender-matched controls during neuropsychological activation with the ST. Magnetic resonance imaging was used for coregistration and for description of the localization of white matter lesions (WML). The cerebral blood flow (CBF) changes during ST were mapped for each of the two study groups, and inter-group differences were calculated on a voxel-by-voxel basis. The patients were followed for 3 to 5 years to ensure diagnostic stability. The control group activated anterior cingulate regions, prefrontal cortices, insula, thalamus and cerebellum. Despite the patients' slower performance with more errors, no significant differences were found comparing the activations in the two groups. The performance was, however, correlated to the number of WML in frontal lobes, insula and adjacent to the basal ganglia, whereas WML in other locations was not related to performance. We thus partly explain the poorer performance by increased frequency of WML in frontostriatal pathways in the depressed patients, impairing neurotransmission.
斯特鲁普测验（ST）用于评估前额叶和扣带回功能的完整性。重度抑郁症患者在ST测验中表现不佳，表明这些区域的功能受到干扰。因此，我们使用正电子发射断层扫描技术，在对41名重度抑郁症住院患者和46名年龄及性别匹配的对照组进行ST神经心理学激活测试期间对他们进行研究。磁共振成像用于配准以及描述白质病变（WML）的定位。为两个研究组中的每一组绘制了ST期间的脑血流量（CBF）变化，并逐体素计算组间差异。对患者进行了3至5年的随访，以确保诊断的稳定性。对照组激活了前扣带回区域、前额叶皮质、脑岛、丘脑和小脑。尽管患者表现较慢且错误较多，但两组激活情况的比较未发现显著差异。然而，表现与额叶、脑岛以及基底神经节附近的WML数量相关，而其他位置的WML与表现无关。因此，我们部分解释了抑郁症患者额纹状体通路中WML频率增加导致表现较差的原因，这损害了神经传递。
