Langenecker Scott A, Jacobs Rachel H, Passarotti Alessandra M
The University of Illinois at Chicago Department of Psychiatry ; The University of Illinois at Chicago Cognitive Neuroscience Center.
The University of Illinois at Chicago Department of Psychiatry ; The University of Illinois at Chicago Cognitive Neuroscience Center ; The University of Illinois at Chicago Institute for Juvenile Research.
Curr Behav Neurosci Rep. 2014 Sep 1;1(3):144-153. doi: 10.1007/s40473-014-0018-x.
Our understanding of the underlying neurobiology for mood disorders is still limited. We present an integrated model for conceptualizing and understanding mood disorders drawing upon a broad literature pertinent to mood disorders. The integrated model of emotion processing and regulation incorporates the linguistic constructs of the Research Domain Criteria (RDoC) initiative. In particular, we focus on the Positive Valence domain/circuit (PVC), highlighting recent reward research and the Negative Valence domain/circuit (NVC), highlighting rumination. Furthermore, we also illustrate the Cognitive Control and Problem Solving (CCaPS) circuit, which is heavily involved in emotion regulation, as well as the default mode network (DMN) and interactions between circuits. We conclude by proposing methods for addressing challenges in the developmental study of mood disorders including using high-risk design that incorporates risk for many disorders.
我们对情绪障碍潜在神经生物学的理解仍然有限。我们提出了一个综合模型，用于基于与情绪障碍相关的广泛文献来概念化和理解情绪障碍。情绪加工与调节的综合模型纳入了研究领域标准（RDoC）计划的语言结构。具体而言，我们聚焦于正性效价领域/环路（PVC），强调近期的奖赏研究，以及负性效价领域/环路（NVC），强调反刍思维。此外，我们还阐述了深度参与情绪调节的认知控制与问题解决（CCaPS）环路，以及默认模式网络（DMN）和各环路之间的相互作用。我们通过提出应对情绪障碍发育研究中挑战的方法来结束本文，这些方法包括使用纳入多种障碍风险的高危设计。
