制动应激诱导大鼠产生抗伤害感受：5-羟色胺与前列腺素的潜在作用

Immobilisation stress-induced antinociception in rats: possible role of serotonin and prostaglandins.

作者信息

Bhattacharya S K, Keshary P R, Sanyal A K

出版信息

Eur J Pharmacol. 1978 Jul 1;50(1):83-5. doi: 10.1016/0014-2999(78)90257-1.

Abstract

Immobilisation of rats for 1, 2 and 4 h induced duration-related antinociception. Antinociception induced by 4 h immobilisation was significantly inhibited after pretreatment by drugs known to inhibit synthesis of serotonin, induce degeneration of serotonergic neurones and inhibit prostaglandin synthesis. The results indicate that immobilisation stress induces autoanalgesia, which may be dependent on the availability of endogenous serotonin and prostaglandins in rat brain.

摘要

将大鼠固定1小时、2小时和4小时会诱导出与时间相关的抗伤害感受。在使用已知可抑制血清素合成、诱导血清素能神经元变性并抑制前列腺素合成的药物进行预处理后，4小时固定诱导的抗伤害感受受到显著抑制。结果表明，固定应激会诱导自身镇痛，这可能取决于大鼠大脑中内源性血清素和前列腺素的可用性。