Thallium induces apoptosis in Jurkat cells.
作者信息
Bragadin Marcantonio, Toninello Antonio, Bindoli Alberto, Rigobello Maria Pia, Canton Marcella
机构信息
Dipartimento di Scienze Ambientali, Università di Venezia, DD2137 30123 Venezia, Italy.
出版信息
Ann N Y Acad Sci. 2003 Dec;1010:283-91. doi: 10.1196/annals.1299.049.
PMID:15033735
Abstract
Thallium induces swelling in mitochondria and apoptosis in Jurkat cells. Both the swelling and the apoptosis are inhibited by means of cyclosporine A (CsA), thus suggesting that these phenomena result from the opening of the membrane transition pore (MTP) in mitochondria. Therefore, apoptosis can be explained as due to the opening of the MTP in mitochondria.
摘要
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