An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival.
作者信息
Arason Gudmundur Jóhann, Bödvarsson Sigurdur, Sigurdarson Sigurudr Thor, Sigurdsson Gardar, Thorgeirsson Gudmundur, Gudmundsson Sveinn, Kramer Judit, Füst Georg
机构信息
Department of Immunology, Institute of Laboratory Medicine and Department of Medicine, Landspítali University Hospital, LSH Hringbraut, 101 Reykjavík, Iceland.
出版信息
Ann N Y Acad Sci. 2003 Dec;1010:496-9. doi: 10.1196/annals.1299.091.
We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B()Q0) and C3 (C3()F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.
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