一种关于衰老、免疫衰老和疫苗反应影响的系统生物学方法。
A systems biology approach to the effect of aging, immunosenescence and vaccine response.
作者信息
Poland Gregory A, Ovsyannikova Inna G, Kennedy Richard B, Lambert Nathaniel D, Kirkland James L
机构信息
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
出版信息
Curr Opin Immunol. 2014 Aug;29:62-8. doi: 10.1016/j.coi.2014.04.005. Epub 2014 May 13.
Abstract
Aging can lead to immunosenescence, which dramatically impairs the hosts' ability to develop protective immune responses to vaccine antigens. Reasons for this are not well understood. This topic's importance is reflected in the increases in morbidity and mortality due to infectious diseases among elderly persons, a population growing in size globally, and the significantly lower adaptive immune responses generated to vaccines in this population. Here, we endeavor to summarize the existing data on the genetic and immunologic correlates of immunosenescence with respect to vaccine response. We cover how the application of systems biology can advance our understanding of vaccine immunosenescence, with a view toward how such information could lead to strategies to overcome the lower immunogenicity of vaccines in the elderly.
摘要
衰老会导致免疫衰老，这会显著损害宿主对疫苗抗原产生保护性免疫反应的能力。其原因尚不完全清楚。这一问题的重要性体现在全球老年人口中因传染病导致的发病率和死亡率上升，以及该人群对疫苗产生的适应性免疫反应显著降低。在此，我们力图总结关于免疫衰老与疫苗反应的遗传和免疫学关联的现有数据。我们探讨了系统生物学的应用如何能增进我们对疫苗免疫衰老的理解，着眼于此类信息如何能催生克服老年人疫苗免疫原性较低问题的策略。
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