Bertoni-Freddari Carlo, Fattoretti Patrizia, Solazzi Moreno, Giorgetti Belinda, Di Stefano Giuseppina, Casoli Tiziana, Meier-Ruge William
Neurobiology of Aging Laboratory, INRCA Research Department, 60121 Ancona, Italy.
Ann N Y Acad Sci. 2003 Dec;1010:635-8. doi: 10.1196/annals.1299.116.
Neuron and synapse numeric densities as well as the average size and surface density of the synaptic junctional areas were measured in the hippocampus and cerebellum of adult, old, and demented (Alzheimer's disease) patients. Our findings support the notion that synaptic loss represents per se a prominent and early damage affecting zones of the central nervous system reported to show a different vulnerability to age- and pathology-related changes.
在成年、老年和痴呆（阿尔茨海默病）患者的海马体和小脑中，测量了神经元和突触的数量密度，以及突触连接区域的平均大小和表面密度。我们的研究结果支持这样一种观点，即突触丧失本身就是一种显著的早期损伤，它会影响中枢神经系统中据报道对与年龄和病理相关变化具有不同易损性的区域。
