Chiang H C, Jaw S M, Chen P M
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, ROC.
Anticancer Res. 1992 Jul-Aug;12(4):1155-62.
Physalins B and F were isolated and characterized from the ethanolic extract of the whole plant of Physalis angulata L. (Solanaceae). Both physalin B and physalin F inhibited the growth of several human leukemia cells: K562 (erythroleukemia), APM1840 (acute T lymphoid leukemia), HL-60 (acute promyelocytic leukemia), KG-1 (acute myeloid leukemia), CTV1 (acute monocytic leukemia) and B cell (acute B lymphoid leukemia). Physalin F showed a stronger activity against these leukemia cells than physalin B, especially against acute myeloid leukemia (KG-1) and acute B lymphoid leukemia (B cell). From the structural features, the active site seems to be the functional epoxy group for physalin F and the double bond for physalin B located at carbon 5 and 6; the former is much more active than the latter as regards anti-leukemic effects.
酸浆苦素B和F是从酸浆（茄科）全株的乙醇提取物中分离并鉴定出来的。酸浆苦素B和F均能抑制多种人类白血病细胞的生长，这些细胞包括：K562（红白血病）、APM1840（急性T淋巴细胞白血病）、HL-60（急性早幼粒细胞白血病）、KG-1（急性髓细胞白血病）、CTV1（急性单核细胞白血病）和B细胞（急性B淋巴细胞白血病）。酸浆苦素F对这些白血病细胞的活性比酸浆苦素B更强，尤其是对急性髓细胞白血病（KG-1）和急性B淋巴细胞白血病（B细胞）。从结构特征来看，酸浆苦素F的活性位点似乎是位于碳5和6处的功能性环氧基团，而酸浆苦素B的活性位点是双键；就抗白血病作用而言，前者比后者活性更强。
