酸浆内酯A，一种新型骨架甾体，以及来自酸浆的其他细胞毒性成分。

Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.

作者信息

Kuo Ping-Chung, Kuo Tsung-Hsiao, Damu Amooru G, Su Chung-Ren, Lee E-Jian, Wu Tian-Shung, Shu Rexen, Chen Chou-Ming, Bastow Kenneth F, Chen Tzu-Hsuan, Lee Kuo-Hsiung

机构信息

Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China.

出版信息

Org Lett. 2006 Jul 6;8(14):2953-6. doi: 10.1021/ol060801s.

DOI:10.1021/ol060801s

PMID:16805525

Abstract

[reaction: see text] A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC(50) values less than 4 microg/mL.

摘要

[反应：见正文] 从酸浆中分离出一种新型的假叶树内酯，即酸浆内酯A（1），其具有前所未有的包含七元环的骨架，以及两种新的酸浆苦素，酸浆苦素U（2）和V（3）。通过光谱分析阐明了其结构，并推测了可能的生物合成途径。酸浆苦素B（4）、D（5）和F（6）对多种肿瘤细胞系，包括KB、A431、HCT-8、PC-3和ZR751，表现出强烈的细胞毒性，半数有效浓度（EC50）值小于4微克/毫升。