四环素决定簇对某些四环素的保护作用不佳：四环素分为两类的进一步证据。
Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes.
作者信息
Oliva B, Chopra I
机构信息
Department of Microbial Biochemistry and Genetics, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965.
出版信息
Antimicrob Agents Chemother. 1992 Apr;36(4):876-8. doi: 10.1128/AAC.36.4.876.
Abstract
Atypical tetracyclines were active against Escherichia coli and Staphylococcus aureus strains containing determinants that mediate resistance to typical tetracyclines by efflux (Tet B and Tet K) or ribosomal protection (Tet M) mechanisms. The results support recently published data that tetracyclines are divisible into at least two classes on the basis of their modes of action.
摘要
非典型四环素对含有通过外排（Tet B和Tet K）或核糖体保护（Tet M）机制介导对典型四环素耐药的决定簇的大肠杆菌和金黄色葡萄球菌菌株具有活性。这些结果支持了最近发表的数据，即四环素可根据其作用方式分为至少两类。
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