Fan Wei, Ellacott Kate L J, Halatchev Ilia G, Takahashi Kanji, Yu Pinxuan, Cone Roger D
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.
Nat Neurosci. 2004 Apr;7(4):335-6. doi: 10.1038/nn1214. Epub 2004 Mar 14.
Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.
下丘脑促阿片黑素细胞皮质素（POMC）神经元有助于调节长期能量储备。在孤束核（NTS）中也发现了POMC神经元，该区域调节饱腹感。我们在此表明，小鼠脑干NTS中的POMC神经元被胆囊收缩素（CCK）和进食诱导的饱腹感激活，并且CCK诱导的进食抑制需要神经元黑素皮质素-4受体（MC4-R）的激活；黑素皮质素系统因此为长期脂肪稳态和短期饱腹感信号的整合提供了一个潜在的基础。
